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60 events in the LIPITOR group)] with a relative risk reduction of 36% [(based on incidences of 1. They are known to be inhibitors of the hydroxymethylglutaryl-CoA reductase enzyme. Drug monograph assignment statins reductase inhibitors mechanism of action: competitively inhibit the reductase enzyme in the. These are used in the treatment of atherosclerosis and various cardiovascular diseases. Indicated as an adjunct to diet for treatment of elevated total-C, Apo B, and TG levels and to increase HDL-C in patients with primary hypercholesterolemia (heterozygous familial and nonfamilial). The symptoms of these effects range from slight myalgia to severe rhabdomyolysis. Statins block the substance which is required to make the cholesterol. It is the class of drugs which decreases the level of cholesterol in the blood. 40 events in the LIPITOR group) or nonfatal MI (108 events in the placebo group vs. 3,9 Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or. May start at 40 mg PO once daily in patients requiring greater than 45% LDL-reduction. [11] The manufacturer Pfizer reported sales of US. The daily dose may be given at any time during the day and without regard to meals Review interprofessional team strategies for improving care coordination and communication to enhance patient adherence to atorvastatin in treating coronary artery disease and hyperlipidemia. 3 Use of statins to target and reduce LDL levels has been shown in a number of landmark studies to significantly reduce the risk of development of CVD and all-cause mortality. Prevents the formation of the PCSK9 protein that promotes the degradation of LDL receptors 1 Elevated cholesterol levels, and in particular, elevated low-density lipoprotein (LDL) levels, are an important risk factor for the development of CVD. Mechanism of Action Statins are HMG-CoA reductase inhibitors Statins, a group of drugs used for the treatment of hypercholesterolemia, have adverse effects on skeletal muscle. Lipitor may cause myopathy (muscle pain, tenderness, or weakness with creatine kinase (CK) above ten times the upper limit of normal) and rhabdomyolysis (with or without acute renal failure secondary to myoglobinuria). Statin medications are used in the management and treatment of hypercholesteremia. Elevated cholesterol levels, and in particular, elevated low-density lipoprotein (LDL) levels, are an important risk factor for the development of CVD. This activity describes the indications, action, and contraindications for statins as a valuable agent in the treatment of hypercholesteremia. [13] [failed verification] Contents. 6,7,8,9,10 Statins are considered a cost-effective treatment option. Elevated levels of cholesterol are linked to cardiovascular disease. However, the mechanism of statins' myotoxic effects is. This activity will highlight the mechanism of action, dosing, monitoring pertinent for. Adults with primary hyperlipidemia (heterozygous familial and nonfamilial) and mixed dyslipidemia Hypertriglyceridemia Primary dysbetalipoproteinemia. Is the first and only siRNA (small interfering RNA) therapy for LDL-C reduction that selectively targets the liver. The best-selling statin is atorvastatin, also known as Lipitor, which in 2003 became the best-selling pharmaceutical in history. Generic Name Clopidogrel DrugBank Accession Number DB00758 Background. Hyperlipidemia – statins are used to reduce harmful levels of cholesterol in the bloodstream. LIPITOR significantly reduced the rate of coronary events [either fatal coronary heart disease (46 events in the placebo group vs. Statins work to lower harmful LDL cholesterol and reduce the long-term risk of heart attack and stroke. Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke. Initially, 10 to 20 mg PO once daily. Works differently than other LDL-C–lowering treatments as a complement to statins 1. It helps in the removal of cholesterol from the blood Review interprofessional team strategies for improving care coordination and communication to enhance patient adherence to atorvastatin in treating coronary artery disease and hyperlipidemia. Rare fatalities have occurred as a result of rhabdomyolysis with statin use, including Lipitor. [12] Due to patent expirations, several statins [specify] became available in 2016 as less expensive generics. The number of patients currently taking statins is estimated to be several millions worldwide. The dosage range is 10 to 80 mg PO once daily (mean LDL reduction range: 43% to 60% LDL).

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